Title of article :
Anti-AIDS Agents. Part 57: Actein, an anti-HIV principle from the rhizome of Cimicifuga racemosa (black cohosh), and the anti-HIV activity of related saponins
Author/Authors :
Nobuko Sakurai، نويسنده , , Jiu-Hong Wu، نويسنده , , Yutaka Sashida، نويسنده , , Yoshihiro Mimaki، نويسنده , , Tamotsu Nikaido، نويسنده , , Kazuo Koike، نويسنده , , Hideji Itokawa، نويسنده , , Kuo-Hsiung Lee، نويسنده ,
Abstract :
Actein (1), a tetracyclic triterpenoid from the rhizome of Cimicifuga racemosa (black cohosh), and 82 related triterpenoid and steroidal saponins isolated from higher plants were evaluated for anti-HIV activity as a continuing study to discover potential anti-AIDS agents from natural products. Actein showed potent activity and another twelve saponins showed moderate activity. The active compounds included two steroidal, seven tetracyclic triterpenoid, and four pentacyclic triterpenoid compounds.
