Author/Authors :
Lee D. Jennings، نويسنده , , Ken W. Foreman، نويسنده , , Thomas S. Rush III، نويسنده , , Desiree H.H. Tsao، نويسنده , , Lidia Mosyak، نويسنده , , Yuanhong Li، نويسنده , , Mohani N. Sukhdeo، نويسنده , , Weidong Ding، نويسنده , , Elizabeth G. Dushin، نويسنده , , Cynthia Hess Kenny، نويسنده , , Soraya L. Moghazeh، نويسنده , , Peter J. Petersen، نويسنده , , Alexey V. Ruzin، نويسنده , , Margareta Tuckman، نويسنده , , Alan G. Sutherland، نويسنده ,
Abstract :
The binding of FtsZ to ZipA is a potential target for antibacterial therapy. Based on a small molecule inhibitor of the ZipA–FtsZ interaction, a parallel synthesis of small molecules was initiated which targeted a key region of ZipA involved in FtsZ binding. The X-ray crystal structure of one of these molecules complexed with ZipA was solved. The structure revealed an unexpected binding mode, facilitated by desolvation of a loosely bound surface water.
Keywords :
Antibacterials , Protein–protein interaction , X-ray crystalstructure , Structure based design.
