Title of article
A novel approach to the synthesis of cytotoxic C2–C3 unsaturated pyrrolo[2,1-c] and benzodiazepines (PBDs) with conjugated acrylyl C2-substituents
Author/Authors
Zhizhi Chen، نويسنده , , Stephen J. Gregson، نويسنده , , Philip W. Howard، نويسنده , , David E. Thurston، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
3
From page
1547
To page
1549
Abstract
A concise synthesis of three novel C2–C3 unsaturated pyrrolo[2,1-c][1,4]benzodiazepine analogues (18–20) containing conjugated acrylyl C2-substituents is reported that utilises Heck coupling to install the C2-acrylyl side chains. These analogues possess significant cytotoxicity according to the NCI 60-cell line screen with 18 surpassing anthramycin (1) in potency.
Keywords
SAR.* Corresponding authors. Tel.: +44-(0)207-753-5932 , e-mail: philip. , PBDs , Cytotoxic , DNA binding
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794231
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