Title of article
Evidences for the formation of bisbenzamidine–heme complexes in cell-free systems
Author/Authors
Annie Mayence، نويسنده , , Jean Jacques Vanden Eynde، نويسنده , , Tien L Huang، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
1625
To page
1628
Abstract
Infrared and colorimetry data suggest that bisbenzamidines connected by various rigid or flexible linkers are able to interact with heme in cell-free systems. At pH 5.0 the inhibition of formation of β-hematin could be ascertained by infrared spectroscopy whereas at pH 7.0 the interaction yielded insoluble complexes for which a sandwich-type structure of stoichiometry 2:1, heme–drug, is tentatively proposed.
Keywords
Bisbenzamidine , Heme , pentamidine , Cell-free systems , Chloroquine.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794247
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