Author/Authors :
Stefan B?urle، نويسنده , , Thorsten Blume، نويسنده , , Judith Günther، نويسنده , , Daniela Henschel، نويسنده , , Roman C. Hillig، نويسنده , , Manfred Husemann، نويسنده , , Anne Mengel، نويسنده , , Christian Parchmann، نويسنده , , Elke Schmid، نويسنده , , Werner Skuballa، نويسنده ,
Abstract :
Based on molecular modeling studies, macrocyclic inhibitors of phosphatase cdc25B were synthetically derived from steroids. A preliminary SAR for this new template was elaborated. A series of compounds shows inhibition of cdc25B in the low micromolar range and good selectivity versus other phosphatases. The compounds did not show a significant antiproliferative effect in MaTu or HaCaT cells.
Keywords :
Steroids , Macrocycles , Molecular modeling , Phosphatases , Templates.
