Title of article :
Methanesulfonamide group at position-4 of the C-5-phenyl ring of 1,5-diarylpyrazole affords a potent class of cyclooxygenase-2 (COX-2) inhibitors
Author/Authors :
Sunil Kumar Singh، نويسنده , , Saibaba Vobbalareddy، نويسنده , , Samala Shivaramakrishna، نويسنده , , A. Krishnamraju، نويسنده , , Shaikh Abdul Rajjak، نويسنده , , Seshagiri Rao Casturi، نويسنده , , Vangoori Akhila، نويسنده , , Yeleswarapu Koteswar Rao، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
The effect of methanesulfonamide (MeSO2NH) group on COX-2 inhibitory activity of 1,5-diarylpyrazole is described. While this group being at position-4 of the N1-phenyl ring was found to be ineffective, its installation at position-4 of the C-5 phenyl ring offered several potent and selective inhibitors of COX-2 with IC50 as low as 30 nM.
Keywords :
Methanesulfonamide , 1 , 5-Diarylpyrazoles , Cyclooxygenase-2 inhibitors.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
