Title of article
A prodrug approach to COX-2 inhibitors with methylsulfone
Author/Authors
Joo-Hyun Moh، نويسنده , , Young Hoon Choi، نويسنده , , Kyoung Min Lim، نويسنده , , Ki-Wha Lee، نويسنده , , Song Seok Shin، نويسنده , , Jin Kyu Choi، نويسنده , , Hyun-Joo Koh، نويسنده , , Chia-Shin Chung، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
1757
To page
1760
Abstract
2,2-Dimethyl-4-phenyl-5-{4-(methylsulfinyl)phenyl}-3(2H)furanone derivatives, 3 and 6, were shown to be effectively transformed in vivo into the corresponding methylsulfone derivatives 1 and 4, when orally administered to rats. Pharmacological implications for use of sulfoxide analogues 3 and 6 are discussed as prodrugs to potent selective COX-2 inhibitors 1 and 4.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794275
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