Author/Authors :
Nagaaki Sato، نويسنده , , Takunobu Shibata، نويسنده , , Makoto Jitsuoka، نويسنده , , Toshiyuki Ohno، نويسنده , , Toshiyuki Takahashi، نويسنده , , Tomoko Hirohashi، نويسنده , , Tetsuya Kanno، نويسنده , , Hisashi Iwaasa، نويسنده , , Akio Kanatani، نويسنده , , Takehiro Fukami، نويسنده ,
Abstract :
A series of substituted 4-alkoxy-2-aminopyridines 2, which were formally derived from neuropeptide Y1 antagonist 1 by replacing the morpholino portion with alkoxy groups, were synthesized and evaluated as neuropeptide Y Y1 receptor antagonists. Primary structure–activity relationships and identification of potent 4-alkoxy derivatives are described.
