Title of article
Isopropyl amide derivatives of potent and selective muscarinic M2 receptor antagonists
Author/Authors
Anandan Palani، نويسنده , , Sundeep Dugar، نويسنده , , John W. Clader، نويسنده , , William J. Greenlee، نويسنده , , Vilma Ruperto، نويسنده , , Ruth A. Duffy، نويسنده , , Jean E. Lachowicz، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
1791
To page
1794
Abstract
Low molecular weight amide derivatives were synthesized and evaluated as M2 receptor antagonists for the treatment of Alzheimerʹs disease. Isopropyl amides 19 and 31 are highly potent, selective and low molecular weight M2 receptor antagonists with structural features different from our clinical candidate 1.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794283
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