Title of article
DNA binding ligands with in vivo efficacy in murine models of bacterial infection: optimization of internal aromatic amino acids
Author/Authors
Roland W. Bürli، نويسنده , , Jacob A. Kaizerman، نويسنده , , Jian-Xin Duan، نويسنده , , Peter Jones، نويسنده , , Kirk W. Johnson، نويسنده , , Mari Iwamoto، نويسنده , , Kiet Truong، نويسنده , , Wenhao Hu، نويسنده , , Timothy Stanton، نويسنده , , Jungkai Alfred Chen، نويسنده , , Sofia Touami، نويسنده , , Matthew Gross، نويسنده , , Vernon Jiang، نويسنده , , Yigong Ge، نويسنده , , Heinz E. Moser، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
6
From page
2067
To page
2072
Abstract
DNA binding ligands with potent antimicrobial activity against Gram-positive bacteria were further optimized by variation of the internal aromatic amino acids. This modification led to compounds with improved in vivo efficacy in lethal murine models of peritonitis (methicillin-resistant S. aureus, MRSA) and lung infection (S. pneumoniae).
Keywords
fax: +1-650-827-0476 , e-mail: hmoser@genesoft.com , antibiotics , Lead optimization , MRSA , DNA ligands.* Corresponding author. Tel.: +1-650-837-1820
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794339
Link To Document