Title of article :
N,N-Dialkyl-4-[(8-azabicyclo[3.2.1]-oct-3-ylidene)phenylmethyl]benzamides, potent, selective δ opioid agonists
Author/Authors :
John R Carson، نويسنده , , Steven J Coats، نويسنده , , Ellen E. Codd، نويسنده , , Scott L. Dax، نويسنده , , Jung Lee، نويسنده , , Rebecca P Martinez، نويسنده , , Lou Anne Neilson، نويسنده , , Philip M Pitis، نويسنده , , Sui-Po Zhang، نويسنده ,
Abstract :
A series of N,N-dialkyl-4-(9-aryltropanylidenemethyl)benzamides was prepared. The lead compounds, 15a and 15c, exhibited extremely high affinity for the δ opioid receptor with excellent selectivity versus the μ opioid receptor. They were full agonists at the δ opioid receptor, as assessed by stimulation of GTPγS binding, and displayed antinociceptive activity.
