Author/Authors :
Emanuela Nizi، نويسنده , , Uwe Koch، نويسنده , , Jesus M Ontoria، نويسنده , , Antonella Marchetti، نويسنده , , Frank Narjes، نويسنده , , Savina Malancona، نويسنده , , Victor G. Matassa، نويسنده , , Cristina Gardelli، نويسنده ,
Abstract :
The N-terminal aminoacid of phenethylamide tripeptide inhibitors of the hepatitis C virus NS3 protease can be replaced with an α-hydroxy acid to obtain more ‘drug like’ inhibitors with low micromolar activity. The preferred S-configuration of the capping residue can be explained by molecular modeling studies.
Keywords :
Phenethylamide dipeptide.* Corresponding author. Tel.: +39-06-91093279 , fax: +39-06-910936-54 , HCV NS3 protease , e-mail: cristina_gardelli@merck.com
