Title of article
Capped dipeptide phenethylamide inhibitors of the HCV NS3 protease
Author/Authors
Emanuela Nizi، نويسنده , , Uwe Koch، نويسنده , , Jesus M Ontoria، نويسنده , , Antonella Marchetti، نويسنده , , Frank Narjes، نويسنده , , Savina Malancona، نويسنده , , Victor G. Matassa، نويسنده , , Cristina Gardelli، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
2151
To page
2154
Abstract
The N-terminal aminoacid of phenethylamide tripeptide inhibitors of the hepatitis C virus NS3 protease can be replaced with an α-hydroxy acid to obtain more ‘drug like’ inhibitors with low micromolar activity. The preferred S-configuration of the capping residue can be explained by molecular modeling studies.
Keywords
Phenethylamide dipeptide.* Corresponding author. Tel.: +39-06-91093279 , fax: +39-06-910936-54 , HCV NS3 protease , e-mail: cristina_gardelli@merck.com
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794357
Link To Document