Title of article
Thioxanthene-derived analogs as σ1 receptor ligands
Author/Authors
Richard A. Glennon، نويسنده , , Abd M Ismaiel، نويسنده , , Seth Ablordeppey، نويسنده , , Mahmoud El-Ashmawy، نويسنده , , James B Fisher، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
2217
To page
2220
Abstract
An investigation of the structure–affinity relationships for the binding of thioxanthene-related structures indicates that an intact thioxanthene ring is not required for binding at σ1 receptors, and that with the appropriate structural modifications, affinity can be enhanced to the subnanomolar level. Certain of the analogs displayed >180-fold selectivity for σ1 versus σ2 receptors.
Keywords
Phenylpentylamines , Antipsychotics , r Receptors.* Corresponding author. Tel.: +1-804-8288487 , e-mail: glennon@hsc.vcu.edu , fax: +1-804-8287404
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794371
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