Title of article
Solid-phase synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors
Author/Authors
James C. Sutton، نويسنده , , Scott A Bolton، نويسنده , , Malcolm E Davis، نويسنده , , Karen S. Hartl، نويسنده , , Bruce Jacobson، نويسنده , , Arvind Mathur، نويسنده , , Martin L. Ogletree، نويسنده , , William A. Slusarchyk، نويسنده , , Robert Zahler، نويسنده , , Steven M. Seiler، نويسنده , , Gregory S. Bisacchi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
7
From page
2233
To page
2239
Abstract
A series of nonguanidine N1-activated C4-carboxy azetidinone tryptase inhibitors was prepared by solid-phase methodology to quickly assess the SAR associated with distal functionality on the N1-activating group. From these studies, potent inhibitors with improved specificity were discovered.
Keywords
Tryptase inhibitor , Azetidinone.* Correspondingauthor. Tel.: +1-609-818-5719 , fax: +1-609-818-6570 , e-mail: james.sutton@bms.com
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794374
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