Title of article
Tight binding ligand approach to oligosaccharide-grafted protein
Author/Authors
Kiichiro Totani، نويسنده , , Ichiro Matsuo، نويسنده , , Yukishige Ito، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
5
From page
2285
To page
2289
Abstract
A novel type of artificial glycoprotein was developed, by using dihydrofolate reductase (DHFR) and methotrexate (MTX) as a protein–ligand pair. Various oligosaccharides linked to MTX were shown to bind tightly with DHFR and afforded oligosaccharide-grafted protein, which could be isolated easily by lectin beads.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794385
Link To Document