Title of article :
Synthesis, SAR, and antitumor properties of diamino-C,N-diarylpyrimidine positional isomers: inhibitors of lysophosphatidic acid acyltransferase-β
Author/Authors :
Baoqing Gong، نويسنده , , Feng Hong، نويسنده , , Cory Kohm، نويسنده , , Scott Jenkins، نويسنده , , John Tulinsky، نويسنده , , Rama Bhatt، نويسنده , , Peter de Vries، نويسنده , , Jack W. Singer، نويسنده , , Peter Klein، نويسنده ,
Abstract :
2,4-Diamino-N4,6-diarylpyrimidines were identified as potent, isoform specific inhibitors of lysophosphatidic acid acyltransferase-β (LPAAT-β). Active inhibitors also blocked proliferation of tumor cell lines in vitro. The effect of 2j in an in vivo tumor model was investigated.
