Title of article
Statin-derived 1,3-oxazinan-2-ones as submicromolar inhibitors of LFA-1/ICAM-1 interaction: stabilization of the metabolically labile vanillyl side chain
Author/Authors
Thomas Ullrich، نويسنده , , Karl Baumann، نويسنده , , Karl Welzenbach، نويسنده , , Simone Schmutz، نويسنده , , Gian Camenisch، نويسنده , , Josef G. Meingassner، نويسنده , , Gabriele Weitz-Schmidt، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
5
From page
2483
To page
2487
Abstract
Modification of the vanillyl substituent on a potent, semisynthetic lymphocyte function-associated antigen (LFA)-1/intercellular adhesion molecule (ICAM)-1 binding inhibitor of the statin family resulted in metabolically more stable analogues that displayed submicromolar inhibitory activity in vitro and considerable anti-inflammatory activity in vivo. The benzodioxole derivative 2b emerged with the best overall profile.
Keywords
statins , Allergic contact dermatitis , Microsomal stability. , LFA-1 inhibitors
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794423
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