Syntheses of sphingosine-1-phosphate analogues and their interaction with EDG/S1P receptors

Sphingosine-1-phosphate (S1P) is an important regulator of a wide variety of biological processes acting as an endogenous ligand to EDG/S1P receptors. In an effort to establish structure–activity relationship between EDG/S1P and ligands, we report herein homology modeling study of EDG-1/S1P1, syntheses of S1P analogues, and cell based binding affinity study for EDG/S1P receptors.