Title of article
New pyrazolo[3,4-d]pyrimidines endowed with A431 antiproliferative activity and inhibitory properties of Src phosphorylation
Author/Authors
S. Schenone، نويسنده , , O. Bruno، نويسنده , , A. Ranise، نويسنده , , F. Bondavalli، نويسنده , , C. Brullo، نويسنده , , P. Fossa، نويسنده , , L. Mosti، نويسنده , , G. Menozzi، نويسنده , , F. Carraro، نويسنده , , A. Naldini، نويسنده , , J. C. Bernini، نويسنده , , F. Manetti، نويسنده , , M. Botta، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
7
From page
2511
To page
2517
Abstract
New 4-aminopyrazolo[3,4-d]pyrimidines bearing various substituents at the position 1 and 6, were synthesized. The new compounds showed antiproliferative activity toward A431 cells, were found to be inhibitors of Src phosphorylation, and induced apoptotic cell death. In particular, 2h was a better inhibitor of Src phosphorylation than the reference compound PP2.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794428
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