Title of article :
Synthesis and biological activity of macrocyclic taxane analogues
Author/Authors :
James G. Tarrant، نويسنده , , Donald Cook، نويسنده , , Craig Fairchild، نويسنده , , John F. Kadow، نويسنده , , Byron H. Long، نويسنده , , William C. Rose، نويسنده , , Dolatrai Vyas، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
A series of paclitaxel analogues possessing a macrocyclic structure between the 7 and 10 positions has been prepared. These compounds possess in vitro activity against a paclitaxel resistant cell line and have in vivo activity comparable to paclitaxel.
Keywords :
paclitaxel , Taxanes , Macrocycles , P-glycoprotein.* Corresponding author at present address: Neurogen Corporation , 35NE Industrial Rd. , Branford , USA. Tel.: +1-203-4888201-x305 , fax: +1-203-4837027 , e-mail: jim_tarrant@nrgn.com , CT 06405
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
