Author/Authors :
Song Wu، نويسنده , , Ping Wang، نويسنده , , Tian-Tian Li، نويسنده , , Lin Wu، نويسنده , , Hanping He، نويسنده , , Xiang Zhou، نويسنده , , Xiaolian Zhang، نويسنده , , Xiaoping Cao، نويسنده ,
Abstract :
meso- and β-Substituted di(pyridiumyl)porphyrins 3, 4, and 7 have been synthesized and their interactions with DNA have been investigated. meso-Substituted porphyrins showed the stronger effect on DNA than that of β-substituted porphyrin. Cytoxicity of compound 3 (IC50) to THP-1 tumor cell was up to 0.11 nM.
