Title of article
A-420983: a potent, orally active inhibitor of lck with efficacy in a model of transplant rejection
Author/Authors
Alexandre P. Kuzin and David W. Borhani، نويسنده , , David J. Calderwood، نويسنده , , Michael M. Friedman، نويسنده , , Gavin C. Hirst، نويسنده , , Biqin Li، نويسنده , , Adelaine K. W. Leung، نويسنده , , Brad McRae، نويسنده , , Sheldon Ratnofsky، نويسنده , , Kurt Ritter، نويسنده , , Wendy Waegell، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
2613
To page
2616
Abstract
We have identified the pyrazolo[3,4-d]pyrimidine A-420983 (compound 7) as a potent inhibitor of lck. A-420983 exhibits oral efficacy in animal models of delayed-type hypersensitivity and organ transplant rejection.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794449
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