Title of article
Advances toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 4
Author/Authors
Vincent P. Rocco، نويسنده , , Patrick G. Spinazze، نويسنده , , Todd J. Kohn، نويسنده , , Nicholas A. Honigschmidt، نويسنده , , Albert L. Lehninger, David L. Nelson, Michael M. Cox، نويسنده , , D. Bradley Wainscott، نويسنده , , Laura J. Ahmad، نويسنده , , Janice Shaw، نويسنده , , Penny G. Threlkeld، نويسنده , , David T. Wong، نويسنده , , Kumiko Takeuchi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
2653
To page
2656
Abstract
A series of 1-(1H-indol-4-yloxy)-3-(4-arylpiperidinyl)propan-2-ols possessing potent dual 5-HT1A receptor antagonism and serotonin reuptake inhibition was discovered. The fused aryl ring moiety contributed to the robust dual activities irrespective of the regiochemistry associated with its connectivity to the piperidine central ring.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794457
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