Title of article
Highly-efficient DNA photocleavers with long wavelength absorptions: thio-heterocyclic fused naphthalimides containing aminoalkyl side chains
Author/Authors
Xuhong Qian، نويسنده , , Yonggang Li، نويسنده , , Yufang Xu، نويسنده , , Yan Liu، نويسنده , , Baoyuan Qu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
2665
To page
2668
Abstract
Thio-heterocyclic fused naphthalimides with aminoalkyl side chains were designed, synthesized and evaluated. These compounds have long wavelength absorptions and binding affinities to Calf thymus DNA. They could photodamage supercoiled pBR322 DNA from form I (closed) to II (nicked) at a concentration as low as 0.5 μM and to form III (linear) at a concentration of 50 μM. A possible mechanism of superoxide anion was provided.
Keywords
DNA photocleaver heterocycle.* Corresponding author. Tel.: +86-411-3673466 , fax: +86-411-36734-88 , e-mail addresses: xhqian@dlut.edu.cn , xhqian@ecust.edu.cn
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794460
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