Title of article
Studies on aromatic compounds: inhibition of calpain I by biphenyl derivatives and peptide-biphenyl hybrids
Author/Authors
Ana Montero، نويسنده , , Mercedes Alonso، نويسنده , , Esperanza Benito، نويسنده , , Antonio Chana، نويسنده , , Enrique Mann، نويسنده , , José M. Navas، نويسنده , , Bernardo Herrad?n، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
5
From page
2753
To page
2757
Abstract
With the objective to understand structural features responsible for the biological activity, novel nonelectrophilic biphenyl derivatives and peptide-biphenyl hybrids have been synthesized and evaluated as calpain I inhibitors. The preliminary results indicate that the presence of additional aromatic rings (besides the biphenyl system) makes these compounds potent calpain inhibitors with IC50 values in the nanomolar range.
Keywords
biphenyl , Calpain inhibitor , Aromatic compounds. , Peptide-biphenyl hybrids
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794477
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