• Title of article

    PDE2 inhibition by the PI3 kinase inhibitor LY294002 and analogues

  • Author/Authors

    Belinda M. Abbott، نويسنده , , Philip E. Thompson، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2004
  • Pages
    5
  • From page
    2847
  • To page
    2851
  • Abstract
    Synthetic 2-morpholinochromones, including the known PI3-kinase inhibitor LY294002, have been evaluated in vitro as inhibitors of isolated human platelet phosphodiesterases. Inhibition of the cAMP-phosphodiesterases, PDE2 and PDE3 by LY294002 is reported for the first time. Preliminary screening across a range of 2-morpholinochromones has revealed structural features for optimised PDE2 inhibition.
  • Keywords
    phosphodiesterase , PDE2 , inhibitor , 2-Morpholinochromone. , LY294002
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2004
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    794495

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=794495