Author/Authors :
Noriyuki Kamei، نويسنده , , Tomohiro Tanaka، نويسنده , , Kentaro Kawai، نويسنده , , Kyosei Miyawaki، نويسنده , , Akihiko Okuyama، نويسنده , , Yoshiko Murakami، نويسنده , , Yoshio Arakawa، نويسنده , , Makoto Haino، نويسنده , , Tatsuhiro Harada، نويسنده , , Masanao Shimano، نويسنده ,
Abstract :
Reverse hydroxamate-based selective TACE inhibitors are described. They have potent TACE inhibitory activities and excellent selectivities against MMP-1, 2, 3, 8, 9, 13, 14, and 17. One representative compound, 18 has demonstrated an excellent oral inhibitory activity of the lipopolysaccharide (LPS)-stimulated TNF-α production in rats.
