Title of article :
Plasmepsin II inhibition and antiplasmodial activity of Primaquine–Statine `double-drugsʹ
Author/Authors :
Sergio Romeo، نويسنده , , Mario DellʹAgli، نويسنده , , Silvia Parapini، نويسنده , , Luca Rizzi، نويسنده , , Germana Galli، نويسنده , , Monica Mondani، نويسنده , , Anna Sparatore، نويسنده , , Donatella Taramelli، نويسنده , , Enrica Bosisio، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
Statine-based inhibitors of Plasmepsin II (PLMII) coupled with Primaquine have been designed using the `double-drugʹ approach. The IC50 values for PLMII inhibition ranged from 0.59 to 400 nM and the best IC50 value for inhibition of Plasmodium falciparum growth in vitro was 0.4 μM, which represent a remarkable improvement compared to other statine-based PLMII inhibitors.
Keywords :
In vitro inhibition. , P. falciparum , Plasmepsin II , Statine , Primaquine , Doubledrug , Chimera drug
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
