Title of article
Synthesis and pharmacological evaluation of piperidinoalkanoyl-1,2,3,4-tetrahydroisoquinoline derivatives as novel specific bradycardic agents
Author/Authors
Hideki Kubota، نويسنده , , Toshihiro Watanabe، نويسنده , , Akio Kakefuda، نويسنده , , Noriyuki Masuda، نويسنده , , Kouichi Wada، نويسنده , , Noe Ishii، نويسنده , , Shuichi Sakamoto، نويسنده , , Shin-ichi Tsukamoto، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
3049
To page
3052
Abstract
A series of piperidinoalkanoyl-1,2,3,4-tetrahydroisoquinoline derivatives were synthesized, and their bradycardic activities were investigated in the isolated right atria of guinea pigs and in conscious rats. These efforts identified the achiral compound 2f, which exhibited potent and long-lasting bradycardic activity with minimal effects on mean blood pressure in conscious rats.
Keywords
Cardiac disease , Myocardial ischemia , Bradycardic agent , Zatebradine.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794532
Link To Document