Title of article
Synthesis of 1,7-annulated indoles and their applications in the studies of cyclin dependent kinase inhibitors
Author/Authors
Guoxin Zhu، نويسنده , , Scott E. Conner، نويسنده , , Xun Zhou، نويسنده , , Ho-Kit Chan، نويسنده , , Chuan Shih، نويسنده , , Thomas A. Engler، نويسنده , , Rima S. Al-awar، نويسنده , , Harold B. Brooks، نويسنده , , Scott A. Watkins، نويسنده , , Charles D. Spencer، نويسنده , , Richard M. Schultz، نويسنده , , Jack A. Dempsey، نويسنده , , Eileen L. Considine، نويسنده , , Bharvin R. Patel، نويسنده , , Catherine A. Ogg، نويسنده , , Vasu Vasudevan، نويسنده , , Michelle L. Lytle، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
5
From page
3057
To page
3061
Abstract
The synthesis of a novel series of 1,7-annulated indolocarbazoles 2 and 16 is described. These compounds were found to be potent cyclin dependent kinase inhibitors with good antiproliferative activity against two human carcinoma cell lines. These inhibitors also arrested tumor cells at the G1 phase and inhibited pRb phosphorylation.
Keywords
1 , 7-Annulatedind ole , Cancer.q Supplementary data associated with this article can be found , in theonline version , D1/CDK4 inhibitor , at 10.1016/j.bmcl.2004.04.033
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794534
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