مرکز منطقه ای اطلاع رساني علوم و فناوري - Development of an isotope-coded activity-based probe for the quantitative profiling of cysteine proteases

Title of article :

Development of an isotope-coded activity-based probe for the quantitative profiling of cysteine proteases

Author/Authors :

Paul F. van Swieten، نويسنده , , Rene Maehr، نويسنده , , Adrianus M.C.H. van den Nieuwendijk، نويسنده , , Benedikt M. Kessler، نويسنده , , Michael Reich، نويسنده , , Chung-Sing Wong، نويسنده , , Hubert Kalbacher، نويسنده , , Michiel A. Leeuwenburgh، نويسنده , , Christoph Driessen، نويسنده , , Gijsbert A. van der Marel، نويسنده , , Hidde L. Ploegh، نويسنده , , Herman S. Overkleeft، نويسنده ,

Issue Information :

روزنامه با شماره پیاپی سال 2004

Pages :

From page :

3131

To page :

3134

Abstract :

Quantification studies of complex protein mixtures have been restricted mainly to whole cell extracts. Here we describe the synthesis of two sets of isotope-coded activity-based probes that allow quantitative functional proteomics experiments on the cathepsins.

Keywords :

cysteine proteases , Active site-directed probe , Isotopiclabeling , suicide inhibitor , synthesis , Chemical proteomics.

Journal title :

Bioorganic & Medicinal Chemistry Letters

Serial Year :

2004

Journal title :

Bioorganic & Medicinal Chemistry Letters

Record number :

794549

Link To Document :

https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=794549