Title of article
Synthesis and evaluation of nonpeptide substituted spirobenzazepines as potent vasopressin antagonists
Author/Authors
Min Amy Xiang، نويسنده , , Robert H. Chen، نويسنده , , Keith T. Demarest، نويسنده , , Joseph Gunnet، نويسنده , , Richard Look، نويسنده , , William Hageman، نويسنده , , William V. Murray، نويسنده , , Donald W. Combs، نويسنده , , Philip J. Rybczynski، نويسنده , , Mona Patel، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
3143
To page
3146
Abstract
A series of substituted spirobenzazepines was prepared and evaluated as V1a and V2 dual vasopressin receptor antagonists. Compounds 7p and 7q have been shown to be not only potent inhibitors of vasopressin receptors, but also have exhibited an excellent overall pharmaceutical suitability profile.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794552
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