Title of article :
Structure-based design, synthesis, and antimicrobial activity of purine derived SAH/MTA nucleosidase inhibitors
Author/Authors :
Martina E. Tedder، نويسنده , , Zhe Nie، نويسنده , , Stephen Margosiak، نويسنده , , Shaosong Chu، نويسنده , , Victoria A. Feher، نويسنده , , Robert Almassy، نويسنده , , J Ernest Villafranca and Krzysztof Appelt، نويسنده , , Kraig M. Yager، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
The structure-based design, synthesis, and biological activity of novel inhibitors of S-adenosyl homocysteine/methylthioadenosine (SAH/MTA) nucleosidase are described. Using 6-substituted purine and deaza purines as the core scaffolds, a systematic and structure guided series of modifications provided low nM inhibitors with broad-spectrum antimicrobial activity.
Keywords :
Structure-based drug design , Antimicrobial.* Corresponding author. Tel.: +1-760-494-6230 , e-mail: kyager@quorex.com , fax: +1-760-602-1915
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
