Author/Authors :
Christian Beaulieu، نويسنده , , Zhaoyin Wang، نويسنده , , Danielle Denis، نويسنده , , Gillian Greig، نويسنده , , Sonia Lamontagne، نويسنده , , Gary OʹNeill، نويسنده , , Deborah Slipetz، نويسنده , , Jennifer Wang، نويسنده ,
Abstract :
A series of 2-substituted N-benzyl benzimidazole containing molecules has been synthesized and its structure–activity relationship for the human DP receptor has been evaluated. Selective DP antagonists with nanomolar potency for the DP receptor were identified in this novel series of benzimidazoles.
Keywords :
DP antagonist.* Corresponding author. Tel.: +1-514-4283297 , fax: +1-514-4284900 , e-mail: christian_beaulieu@merck.com , Benzimidazole
