Author/Authors :
Yasuyuki Takeda، نويسنده , , Kouichi Uoto، نويسنده , , Michio Iwahana، نويسنده , , Takeshi Jimbo، نويسنده , , Motoko Nagata، نويسنده , , Ryo Atsumi، نويسنده , , Chiho Ono، نويسنده , , Noriko Tanaka، نويسنده , , Hirofumi Terasawa، نويسنده , , Tsunehiko Soga، نويسنده ,
Abstract :
To improve the metabolic stability of 3, which exhibited both in vitro antitumor activity and in vivo efficacy by both iv and po administration, we designed and synthesized new taxane analogues. Most of the synthetic compounds maintained excellent antitumor activity and were scarcely metabolized by human liver microsomes. And some compounds exhibited potent antitumor effects against B16 melanoma BL6 in vivo by both iv and po administration similarly to 3.
