Title of article
Design and synthesis of dysidiolide analogs from vitamin D3: novel class of Cdc25A inhibitors
Author/Authors
Rumiko Shimazawa، نويسنده , , Toshiyuki Suzuki، نويسنده , , Kosuke Dodo، نويسنده , , Ryuichi Shirai، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
3291
To page
3294
Abstract
Potent dysidiolide analogs were synthesized by structural hybridization of dysidiolide and vitamin D3. These analogs exhibited strong inhibitory activity toward dual-specificity phosphatase Cdc25A (IC50=0.44–0.89 μM).
Keywords
Dual-specificity phosphatase , Enzymeinhibitor , Cdc25A , Vitamin D3. , Dysidiolide
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794582
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