Title of article
Thiol-based SAHA analogues as potent histone deacetylase inhibitors
Author/Authors
Takayoshi Suzuki، نويسنده , , Akiyasu Kouketsu، نويسنده , , Azusa Matsuura، نويسنده , , Arihiro Kohara، نويسنده , , Shin-ichi Ninomiya، نويسنده , , Kohfuku Kohda، نويسنده , , Naoki Miyata، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
5
From page
3313
To page
3317
Abstract
In order to find novel nonhydroxamate histone deacetylase (HDAC) inhibitors, a series of thiol-based compounds modeled after suberoylanilide hydroxamic acid (SAHA) was synthesized, and their inhibitory effect on HDACs was evaluated. Compound 6, in which the hydroxamic acid of SAHA was replaced by a thiol, was found to be as potent as SAHA, and optimization of this series led to the identification of HDAC inhibitors more potent than SAHA.
Keywords
SAHA , HDAC , Zinc protein.* Corresponding authors. Tel./fax: +81-52-836-3407 , Enzyme inhibitor , miyata-n@phar.nagoya-cu.ac.jp , e-mail addresses:suzuki@phar.nagoya-cu.ac.jp
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794587
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