Title of article :
6-Arylamino-7-chloro-quinazoline-5,8-diones as novel cytotoxic and DNA topoisomerase inhibitory agents
Author/Authors :
Hyen Joo Park، نويسنده , , Young Shin Kim، نويسنده , , Jin Sung Kim، نويسنده , , Eun-Jin Lee، نويسنده , , You-Jin Yi، نويسنده , , Hye Jin Hwang، نويسنده , , Myung-Eun Suh، نويسنده , , Chung-Kyu Ryu، نويسنده , , Sang Kook Lee، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
A series of 6-arylamino-7-chloro-quinazoline-5,8-diones were prepared and evaluated for their in vitro cytotoxicity in cultured human cancer cell lines A549 (lung cancer), Col2 (colon cancer), and SNU-638 (stomach cancer). The preliminary structure–activity relationship has been described for providing further development of potent antitumor agents. To further investigate the cytotoxic mechanism, the effects of test compounds on DNA topoisomerase I and II activities have been assessed.
Keywords :
8-diones , cytotoxicity , Topoisomerase inhibitor. , 6-Arylamino-7-chloro-quinazoline-5
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
