Title of article
Synthesis and anticancer activity of side chain analogs of the crambescidin alkaloids
Author/Authors
Zachary D. Aron، نويسنده , , Halina Pietraszkiewicz، نويسنده , , Larry E. Overman، نويسنده , , Fredrick Valeriote، نويسنده , , Carman Cuevas، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
5
From page
3445
To page
3449
Abstract
Twenty three side chain analogs of the crambescidin alkaloids were prepared from the corresponding pentacyclic zwitterionic core acid. In the crambescidin 800 and 657 series, potency increased with increasing chain length. In addition, substantial variations in tumor selectivity with structure were seen. Crambescidin analogs having short, nonpolar side chains were identified for the first time as promising anticancer agents.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794613
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