Title of article
Design and synthesis of oxadiazolidinediones as inhibitors of plasminogen activator inhibitor-1
Author/Authors
Ariamala Gopalsamy، نويسنده , , Scott L. Kincaid، نويسنده , , John W. Ellingboe، نويسنده , , Thomas M. Groeling، نويسنده , , Thomas M. Antrilli، نويسنده , , Girija Krishnamurthy، نويسنده , , Ann Aulabaugh، نويسنده , , Gregory S. Friedrichs، نويسنده , , David L. Crandall، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
3477
To page
3480
Abstract
A novel series of PAI-1 inhibitors containing an oxadiazolidinedione moiety were identified by high through-put screening. Optimization of substituents by parallel synthesis and the iterative design toward understanding structure–activity relationship to improve potency are described.
Keywords
PAI-1 inhibitor , fax: +1-845-602-3045 , Parallel synthesis.* Corresponding author. Tel.: +1-845-602-2841 , Oxadiazolidine diones , e-mail: gopalsa@wyeth.com
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794618
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