Author/Authors :
F. Kuo، نويسنده , , T. A. Gillespie، نويسنده , , P. Kulanthaivel، نويسنده , , R. J. Lantz، نويسنده , , T. W. Ma، نويسنده , , D. L. Nelson، نويسنده , , P. G. Threlkeld، نويسنده , , W. J. Wheeler، نويسنده , , P. Yi، نويسنده , , M. Zmijewski، نويسنده ,
Abstract :
Several putative phase I duloxetine metabolites, 4-hydroxy-, 5-hydroxy-, 6-hydroxy-, 5-hydroxy-6-methoxy-, 6-hydroxy-5-methoxy-, 5,6-dihydroxy-, and 4,6-dihydroxyduloxetine were synthesized, and their phase II metabolite as glucuronide or sulfate conjugates were also synthesized. Their in vitro binding activities were compared to that of parent compound duloxetine.
