Title of article
Aggregation and G-quadruplex DNA-binding study of 6a,12a-diazadibenzo-[a,g]fluorenylium derivative
Author/Authors
Bernard Juskowiak، نويسنده , , Elzbieta Galezowska، نويسنده , , Natalia Koczorowska، نويسنده , , Tadeusz W Hermann، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
3627
To page
3630
Abstract
The aggregation and DNA binding behavior of a new G-quadruplex selective ligand, 6a,12a-diazadibenzo-[a,g]fluorenylium derivative, was studied by UV–vis absorption and fluorescence spectroscopy. The formation of ligand aggregates with different spectral characteristics was observed at low and high concentration of NaCl, respectively. The ligand binds to G-quadruplex with much higher affinity than to single- and double-stranded DNA.
Keywords
fluorescence , Fluorenylium derivative , DNAbinding , G-quadruplex DNA. , Aggregation
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794649
Link To Document