Title of article
Synthesis and evaluation of substrate-mimicking cytosolic phospholipase A2 inhibitors––reducing the lipophilicity of the arachidonyl chain isostere
Author/Authors
Iain Walters، نويسنده , , Colin Bennion، نويسنده , , Stephen Connolly، نويسنده , , Pamela J Croshaw، نويسنده , , Kim Hardy، نويسنده , , Paul Hartopp، نويسنده , , Clive G Jackson، نويسنده , , Sarah J King، نويسنده , , Louise Lawrence، نويسنده , , Antonio Mete، نويسنده , , David Murray، نويسنده , , David H Robinson، نويسنده , , Linda Stein، نويسنده , , Edward Wells، نويسنده , , W John Withnall، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
5
From page
3645
To page
3649
Abstract
The high lipophilicity of a series of cytosolic phospholipase A2 inhibitors has been reduced by the modification of a decyloxyphenyl chain designed to mimic the arachidonyl group of the natural substrate. These changes have resulted in an improvement in the whole cell potency of the inhibitors.
Keywords
cPLA2 inhibition , Arachidonyl chain mimic.* Corresponding author. Tel.: +44-1509-644001 , fax: +44-1509-6455-71 , e-mail: iain.walters@astrazeneca.com
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794653
Link To Document