Author/Authors :
B. Narasimhulu Naidu، نويسنده , , Margaret E. Sorenson، نويسنده , , Thomas Hudyma، نويسنده , , Xiaofan Zheng، نويسنده , , Yunhui Zhang، نويسنده , , Joanne J. Bronson، نويسنده , , Michael J. Pucci، نويسنده , , Junius M Clark، نويسنده , , Yasutsugu Ueda، نويسنده ,
Abstract :
The synthesis and antibacterial activity of a series of new nocathiacin I derivatives (1–12) containing polar water solubilizing groups is described. Most of these compounds exhibited potent antibacterial activity and have improved water solubility. In addition, compounds 5, 7–9 also exhibited potent in vivo activity.
Keywords :
Antibacterial activity , Nocathiacin , Natural product.* Corresponding author. Tel.: +1-203-677-6574 , fax: +1-203-677-7702 , e-mail: narasimhulu.naidu@bms.com
