Title of article
Synthesis and structure–activity relationship of novel benzoxazole derivatives as melatonin receptor agonists
Author/Authors
Li-Qiang Sun، نويسنده , , Jie Chen، نويسنده , , Marc Bruce، نويسنده , , Jeffrey A. Deskus، نويسنده , , James R. Epperson، نويسنده , , Katherine Takaki، نويسنده , , Graham Johnson، نويسنده , , Lawrence Iben، نويسنده , , Cathy D. Mahle، نويسنده , , Elaine Ryan، نويسنده , , Cen Xu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
3799
To page
3802
Abstract
A series of benzoxazole derivatives was synthesized and evaluated as melatoninergic ligands. The binding affinity of these compounds for human MT1 and MT2 receptors was determined using 2-[125I]-iodomelatonin as the radioligand. From this series of benzoxazole derivatives, compounds 14 and 17 were identified as melatonin receptor agonists.
Keywords
melatonin , Melatonin Receptors , Agonists , Benzoxazole.* Corresponding author. Tel.: +1-203-677-7460 , fax: +1-203-677-7702 , e-mail: sunl@bms.com
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794684
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