Title of article
Novel dual inhibitors of calpain and lipid peroxidation
Author/Authors
Serge Auvin، نويسنده , , Bernadette Pignol، نويسنده , , Edith Navet، نويسنده , , Dominique Pons، نويسنده , , Jean-G Marin، نويسنده , , Dennis Bigg، نويسنده , , Pierre-Etienne Chabrier، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
4
From page
3825
To page
3828
Abstract
A series of molecules with dual inhibitory activities on calpain and lipid peroxidation were synthesized. These hybrid compounds were built on the calpain pharmacophore 2-hydroxytetrahydrofuran linked to a set of antioxidants via a l-leucine linker. Compound 7, the most potent in cellular calpain and lipid peroxidation inhibitions, provided effective protection against glial cell death induced by maitotoxin.
Keywords
Calpain inhibition , Antioxidants.* Corresponding author. Tel.: +33-16092-2003 , e-mail: serge.auvin@ipsen.com , fax: +33-16907-3802
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794689
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