Title of article
Quinoxaline N,N′-dioxide derivatives and related compounds as growth inhibitors of Trypanosoma cruzi. Structure–activity relationships
Author/Authors
Gabriela Aguirre، نويسنده , , Hugo Cerecetto، نويسنده , , Rossanna Di Maio، نويسنده , , Mercedes Gonzalez-Wangüemert، نويسنده , , Mar??a Elena Montoya Alfaro، نويسنده , , Andrés Jaso، نويسنده , , Belén Zarranz، نويسنده , , Miguel ?ngel Ortega، نويسنده , , Ignacio Aldana، نويسنده , , Antonio Monge-Vega، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
5
From page
3835
To page
3839
Abstract
Quinoxaline derivatives presented good inhibitor activity of growth of Trypanosoma cruzi in in vitro assays. The 50% inhibitory doses were of the same order of that of Nifurtimox. Derivative 13, a quinoxaline N,N′-dioxide derivative, and the reduced derivatives 19 and 20 were the most cytotoxic compounds against the protozoan. Structural requirements for optimal activity were studied by computational methods. From statistical analysis we could establish a multiple correlation between activity and lipophilic properties and LUMO energy.
Keywords
Growth inhibitors , Trypanosoma cruzi , Anti-parasiticagents.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794691
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