Author/Authors :
Gabriela Aguirre، نويسنده , , Hugo Cerecetto، نويسنده , , Rossanna Di Maio، نويسنده , , Mercedes Gonzalez-Wangüemert، نويسنده , , Mar??a Elena Montoya Alfaro، نويسنده , , Andrés Jaso، نويسنده , , Belén Zarranz، نويسنده , , Miguel ?ngel Ortega، نويسنده , , Ignacio Aldana، نويسنده , , Antonio Monge-Vega، نويسنده ,
Abstract :
Quinoxaline derivatives presented good inhibitor activity of growth of Trypanosoma cruzi in in vitro assays. The 50% inhibitory doses were of the same order of that of Nifurtimox. Derivative 13, a quinoxaline N,N′-dioxide derivative, and the reduced derivatives 19 and 20 were the most cytotoxic compounds against the protozoan. Structural requirements for optimal activity were studied by computational methods. From statistical analysis we could establish a multiple correlation between activity and lipophilic properties and LUMO energy.
