Title of article
Application of multi-component reactions to antimalarial drug discovery. Part 1: Parallel synthesis and antiplasmodial activity of new 4-aminoquinoline Ugi adducts
Author/Authors
Chitalu C Musonda، نويسنده , , Dale Taylor، نويسنده , , Julie Lehman، نويسنده , , Jiri Gut، نويسنده , , Philip J. Rosenthal، نويسنده , , Kelly Chibale، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
5
From page
3901
To page
3905
Abstract
The synthesis of a new class of Ugi adducts incorporating the 4-aminoquinoline moiety is described. The novel compounds are active against both chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum with the best compound showing an IC50 value of 73 nM against a resistant K1 strain.
Keywords
malaria , 4-Aminoquinolines. , Ugi isocyanide multi-component reactions
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2004
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
794703
Link To Document