• Title of article

    Intrinsic factor-mediated modulation of cyanocobalamin–N-sulfonyl-acridinium-9-carboxamide chemiluminescence

  • Author/Authors

    Maciej Adamczyk، نويسنده , , Donald D. Johnson، نويسنده , , Phillip G. Mattingly، نويسنده , , Jeffrey A Moore، نويسنده , , You Pan، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2004
  • Pages
    5
  • From page
    3917
  • To page
    3921
  • Abstract
    Two cyanocobalamin–N-sulfonyl-acridinium-9-carboxamides with linkage through the N10 or 9-position were prepared from B12-e-carboxylic acid. The noncovalent association of intrinsic factor with these ligands resulted in specific modulation of the associated chemiluminescence signal either by quenching or changing the emission profile. Either effect was sufficient to formulate a homogeneous assay to detect vitamin B12 in buffer.
  • Keywords
    Cobalamin. , Homogeneous chemiluminescent assays , Intrinsic factor , vitamin B12
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2004
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    794706

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=794706