Title of article :
Design and synthesis of 3-(2-pyridyl)pyrazolo[1,5-a]pyrimidines as potent CRF1 receptor antagonists
Author/Authors :
Charles Q. Huang، نويسنده , , Keith M Wilcoxen، نويسنده , , Dimitri E. Grigoriadis، نويسنده , , James R McCarthy، نويسنده , , Chen Chen، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
A series of 3-(2-pyridyl)pyrazolo[1,5-a]pyrimidines was designed and synthesized as antagonists for the corticotrophin-releasing factor-1 (CRF1) receptor. Several compounds such as 20c (Ki=10 nM) exhibited good binding affinities at the CRF1 receptor. In addition, 20c had adequate solubility in water.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
